Surprising protein links dietary restriction to increased lifespan in flies

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02774-0A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extens…

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02774-0

A fruit-fly protein thought only to store amino acids in fact responds to nutritional deficiency in both development and adulthood, resulting in lifespan extension.

Single-cell atlas of transcriptomic vulnerability across brain disorders

Nature, Published online: 23 September 2026; doi:10.1038/s41586-025-09573-zA population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in neurod…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-025-09573-z

A population-scale single-cell transcriptomic atlas of the human dorsolateral prefrontal cortex provides a perspective of the transcriptomic landscape in neurodegenerative and neuropsychiatric disorders, and offers potential targets for therapeutic intervention.

Genome project opens the next chapter for studying bat evolution

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02637-8A landmark collection of bat genomes reveals fresh clues about the evolution of one of the world’s most unusual groups of mammals.

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02637-8

A landmark collection of bat genomes reveals fresh clues about the evolution of one of the world’s most unusual groups of mammals.

The lipidomic architecture of the mouse brain

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11050-0A spatial lipidomic atlas of the mouse brain reveals more than 500 biochemical territories that mirror cell types and connectivity, capture oligodendrocyte hete…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11050-0

A spatial lipidomic atlas of the mouse brain reveals more than 500 biochemical territories that mirror cell types and connectivity, capture oligodendrocyte heterogeneity and ventricular zonation, and are remodelled during pregnancy.

A widespread agricultural practice is an unexpected CO<sub>2</sub> sink

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02646-7‘Liming’ to reduce soil acidity has long been considered a carbon dioxide source, but in North America’s largest river basin, it has resulted in net capture of …

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02646-7

‘Liming’ to reduce soil acidity has long been considered a carbon dioxide source, but in North America’s largest river basin, it has resulted in net capture of atmospheric carbon.

Lsp2 links early-life diet to adult translation and lifespan in <i>Drosophila</i>

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11031-3Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan t…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11031-3

Isotope tracing is used to determine the fate of larval dietary amino acids in adult flies, and identifies Lsp2 as a key regulator of translation and lifespan that forms the molecular basis of the effects of early-life protein restriction.

Lsp2 links mTORC1 to TOP mRNA translation and lifespan in <i>Drosophila</i>

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11029-xIn Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Ls…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11029-x

In Drosophila, the protein Lsp2, which is induced by dietary essential amino acids, is a key physiological effector of mTORC1, and mutant flies that lack the Lsp2 gene exhibit reduced translation of TOP mRNAs and improved longevity.

Gravitational forces inside Earth drag some decades out — and make others fly by

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02773-1Variations in day length that occur on multidecadal timescales are caused by gravitational coupling between Earth’s inner core and its solid mantle.

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02773-1

Variations in day length that occur on multidecadal timescales are caused by gravitational coupling between Earth’s inner core and its solid mantle.

TRAM promotes Toll-like-receptor-free myddosome signal transduction

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11052-yTRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal tra…

Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11052-y

TRAM is a regulator of myddosome assembly through dissociating MyD88 from the TLR–TIRAP complex to enable myddosome maturation and durable downstream signal transduction.

Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02770-4Single-nucleus RNA sequencing captures molecular changes in the prefrontal cortex across the lifespan and in health and disease.

Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02770-4

Single-nucleus RNA sequencing captures molecular changes in the prefrontal cortex across the lifespan and in health and disease.